HIBISCUS SABDARIFFA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Hibiscus sabdariffa is a plant considered safe in common food amounts. As a tea, it may be beneficial for high blood pressure.

The fruit acids in Hibiscus sabdariffa might work like a laxative. Other chemicals in Hibiscus sabdariffa might be able to lower blood pressure, reduce levels of sugar and fats in the blood, reduce swelling, and work like antibiotics.

People use Hibiscus sabdariffa for high blood pressure, high cholesterol, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness ?

Possibly Effective for

High blood pressure. Drinking Hibiscus sabdariffa tea or taking Hibiscus sabdariffa extract by mouth seems to lower blood pressure by a small amount in people with normal or high blood pressure.

There is interest in using Hibiscus sabdariffa for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Hibiscus sabdariffa is commonly consumed in foods. It is possibly safe when used in medicinal amounts. Hibiscus sabdariffa tea has been used safely in amounts of up to 720 mL daily for up to 6 weeks. Side effects are uncommon but might include stomach upset, gas, and constipation.

Special Precautions and Warnings

Pregnancy: Hibiscus sabdariffa is possibly unsafe to use during pregnancy. It might stimulate a menstrual cycle or have effects that might terminate pregnancy. Stay on the safe side and avoid use.

Breast-feeding: Hibiscus sabdariffa is possibly unsafe to use while breast-feeding. It might have effects that can be harmful to the infant. Stay on the safe side and avoid use.

Children: Hibiscus sabdariffa is possibly safe when used at a dose of 2 grams by mouth three times daily for up to 4 weeks in adolescents 12-18 years of age. There isn’t enough reliable information to know if it is safe for children under 12 years old.

Surgery: Hibiscus sabdariffa might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using Hibiscus sabdariffa at least 2 weeks before a scheduled surgery.

Interactions ?

Major Interaction

Do not take this combination

Chloroquine (Aralen) interacts with HIBISCUS SABDARIFFA
Hibiscus sabdariffa tea might reduce the amount of chloroquine that the body can absorb and use. Taking Hibiscus sabdariffa tea along with chloroquine might reduce the effects of chloroquine. People taking chloroquine for the treatment or prevention of malaria should avoid Hibiscus sabdariffa products.

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with HIBISCUS SABDARIFFA
Hibiscus sabdariffa might lower blood sugar levels. Taking Hibiscus sabdariffa along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely. Hibiscus sabdariffa might increase blood sugar levels. Taking Hibiscus sabdariffa along with diabetes medications might reduce the effects of these medications. Monitor your blood sugar closely.
Medications for high blood pressure (Antihypertensive drugs) interacts with HIBISCUS SABDARIFFA
Hibiscus sabdariffa might lower blood pressure. Taking Hibiscus sabdariffa along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Simvastatin (Zocor) interacts with HIBISCUS SABDARIFFA
Hibiscus sabdariffa might increase how quickly the body gets rid of simvastatin. Taking Hibiscus sabdariffa with simvastatin might decrease the effects of simvastatin.
Diclofenac (Voltaren, others) interacts with HIBISCUS SABDARIFFA
Taking Hibiscus sabdariffa while taking diclofenac might alter levels of diclofenac in the body. This might change the effects and side effects of diclofenac.
Losartan (Cozaar) interacts with HIBISCUS SABDARIFFA
Taking Hibiscus sabdariffa with losartan might increase the levels of losartan in the body. This might increase the effects and side effects of losartan.

Minor Interaction

Be watchful with this combination

Acetaminophen (Tylenol, others) interacts with HIBISCUS SABDARIFFA
Drinking a Hibiscus sabdariffa beverage before taking acetaminophen might increase how fast the body gets rid of acetaminophen. But more information is needed to know if this is a big concern.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2A6 (CYP2A6) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C8 (CYP2C8) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HIBISCUS SABDARIFFA
Some medications are changed and broken down by the liver. Hibiscus sabdariffa might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Hibiscus sabdariffa has most often been used by adults as a powder, extract, or tea for 4-12 weeks. Speak with a healthcare provider to find out what dose or product might be best for a specific condition.

View References

REFERENCES:

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Mozaffari-Khosravi, H., Jalali-Khanabadi, B. A., Afkhami-Ardekani, M., and Fatehi, F. Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern.Complement Med 2009;15(8):899-903. View abstract.

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Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2020:1-11. View abstract.

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Al-Anbaki M, Nogueira RC, Cavin AL, et al. Treating uncontrolled hypertension with Hibiscus sabdariffa when standard treatment is insufficient: Pilot intervention. J Altern Complement Med. 2019;25(12):1200-1205. View abstract.

Alam MA, Bin Jardan YA, Alzenaidy B, et al. Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine. J Pharm Pharmacol 2021;73(9):1151-60. View abstract.

Alarcón-Alonso J, Zamilpa A, Aguilar FA, Herrera-Ruiz M, Tortoriello J, Jimenez-Ferrer E. Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. J Ethnopharmacol. 2012 Feb 15;139(3):751-6. View abstract.

Asgary S, Soltani R, Zolghadr M, Keshvari M, Sarrafzadegan N. Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: a double-blind placebo-controlled clinical trial. J Complement Integr Med. 2016;13(2):175-80. View abstract.

Aziz Z, Wong SY, Chong NJ. Effects of Hibiscus sabdariffa L. on serum lipids: a systematic review and meta-analysis. J Ethnopharmacol. 2013 Nov 25;150(2):442-50. View abstract.

Barletta C, Paccone M, Uccello N, et al. Efficacy of food supplement Acidif plus in the treatment of uncomplicated UTIs in women: a pilot observational study. Minerva Ginecol. 2020;72(2):70-74. View abstract.

Boix-Castejón M, Herranz-López M, Pérez Gago A, et al. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food Funct. 2018;9(6):3173-3184. View abstract.

Builders PF, Kabele-Toge B, Builders M, Chindo BA, Anwunobi PA, Isimi YC. Wound healing potential of formulated extract from hibiscus sabdariffa calyx. Indian J Pharm Sci. 2013 Jan;75(1):45-52. View abstract.

Bule M, Albelbeisi AH, Nikfar S, Amini M, Abdollahi M. The antidiabetic and antilipidemic effects of Hibiscus sabdariffa: A systematic review and meta-analysis of randomized clinical trials. Food Res Int. 2020;130:108980. View abstract.

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Chiu HF, Liao YR, Shen YC, et al. Improvement on blood pressure and skin using roselle drink: A clinical trial. J Food Biochem 2022;46(10):e14287. View abstract.

Chou ST, Lo HY, Li CC, Cheng LC, Chou PC, Lee YC, Ho TY, Hsiang CY. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation. J Ethnopharmacol. 2016 Dec 24;194:617-625. View abstract.

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Diantini A, Rahmat S, Alpiani A, Sumiwi SA, Lubis L, Levita J. Effect of the roselle (Hibiscus sabdariffa L.) calyces drink on the physiological parameters of healthy adult subjects. Biomed Rep 2021;15(5):89. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Elkafrawy N, Younes K, Naguib A, et al. Antihypertensive efficacy and safety of a standardized herbal medicinal product of Hibiscus sabdariffa and Olea europaea extracts (NW Roselle): A phase-II, randomized, double-blind, captopril-controlled clinical trial. Phytother Res. 2020;34(12):3379-3387.View abstract.

Fakeye TO, Adegoke AO, Omoyeni OC, Famakinde AA. Effects of water extract of Hibiscus sabdariffa, Linn (Malvaceae) 'Roselle' on excretion of a diclofenac formulation. Phytother Res. 2007;21(1):96-8. View abstract.

García-Muñoz AM, García-Guillén AI, Victoria-Montesinos D, Abellán-Ruiz MS, Alburquerque-González B, Cánovas F. Effect of the Combination of Hibiscus sabdariffa in Combination with Other Plant Extracts in the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis. Foods 2023;12(11):2269. View abstract.

Hadi A, Pourmasoumi M, Kafeshani M, Karimian J, Maracy MR, Entezari MH. The Effect of Green Tea and Sour Tea (Hibiscus sabdariffa L.) Supplementation on Oxidative Stress and Muscle Damage in Athletes. J Diet Suppl. 2017 May 4;14(3):346-357. View abstract.

Herranz-López M, Olivares-Vicente M, Boix-Castejón M, Caturla N, Roche E, Micol V. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Sci Rep. 2019;9(1):2999. View abstract.

Iyare EE, Adegoke OA. Maternal consumption of an aqueous extract of Hibiscus sabdariffa during lactation accelerates postnatal weight and delays onset of puberty in female offspring. Niger J Physiol Sci. 2008 Jun-Dec;23(1-2):89-94. View abstract.

Jalalyazdi M, Ramezani J, Izadi-Moud A, Madani-Sani F, Shahlaei S, Ghiasi SS. Effect of hibiscus sabdariffa on blood pressure in patients with stage 1 hypertension. J Adv Pharm Technol Res. 2019;10(3):107-111. View abstract.

Johnson SS, Oyelola FT, Ari T, Juho H. In vitro inhibitory activities of the extract of Hibiscus sabdariffa L. (family Malvaceae) on selected cytochrome P450 isoforms. Afr J Tradit Complement Altern Med. 2013 Apr 12;10(3):533-40. View abstract.

Kolawole JA, Maduenyi A. Effect of zobo drink (Hibiscus sabdariffa water extract) on pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet 2004;29:25-9. View abstract.

Kuriyan R, Kumar DR, Rajendran R, Kurpad AV. An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial. BMC Complement Altern Med 2010;10:27. View abstract.

Lee CH, Kuo CY, Wang CJ, Wang CP, Lee YR, Hung CN, Lee HJ. A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro. Biosci Biotechnol Biochem. 2012;76(4):646-51. View abstract.

Levrini L, Azzi L, Bossi S. The efficacy of a dietary supplement with carnosine and Hibiscus sabdariffa L. (AqualiefTM) in patients with xerostomia: a randomized, placebo-controlled, double-blind trial. Clin Ter 2020;171(4):e295-e301. View abstract.

Marhuenda J, Pérez-Piñero S, Arcusa R, et al. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of a polyphenolic extract (Hibiscus sabdariffa and Lippia citriodora) for reducing blood pressure in prehypertensive and type 1 hypertensive subjects. Molecules. 2021;26(6):1783. View abstract.

McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus Sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr 2010;140:298-303. View abstract.

Micucci M, Angeletti A, Cont M, Corazza I, Aldini R, Donadio E, Chiarini A, Budriesi R. Hibiscus Sabdariffa L. Flowers and Olea Europea L. Leaves Extract-Based Formulation for Hypertension Care: In Vitro Efficacy and Toxicological Profile. J Med Food. 2016 May;19(5):504-12. View abstract.

Milandri R, Maltagliati M, Bocchialini T, et al. Effectiveness of D-mannose, Hibiscus sabdariffa and Lactobacillus plantarum therapy in prevention of infectious events following urodynamic study. Urologia. 2019;86(3):122-125. View abstract.

Mohagheghi A, Maghsoud S, Khashayar P, Ghazi-Khansari M. The effect of hibiscus sabdariffa on lipid profile, creatinine, and serum electrolytes: a randomized clinical trial. ISRN Gastroenterol. 2011;2011:976019. View abstract.

Mohamed R, Fernandez J, Pineda M, Aguilar M. Roselle (Hibiscus sabdariffa) seed oil Is a rich source of gamma-tocopherol. J Food Sci 2007;72:S207-11.

Mojiminiyi F, Aliyu B, Oyeniran O, Isu A. The hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa may occur through the attenuation of Autonomic nervous system activity. Niger J Physiol Sci 2021;36(2):203-209. View abstract.

Mojiminiyi F, Aliyu B, Oyeniyi Y, Isezuo S, Alada A. The Effect of Acute Administration of the Aqueous Calyx Extract of Hibiscus sabdariffa on Blood pressure, Heart rate and Double Product of Apparently Healthy Human Subjects during Different Postures. Niger J Physiol Sci 2022;37(1):147-152. View abstract.

Mozaffari-Khosravi H, Ahadi Z, Barzegar K. The effect of green tea and sour tea on blood pressure of patients with type 2 diabetes: a randomized clinical trial. J Diet Suppl. 2013 Jun;10(2):105-15. View abstract.

Najafpour Boushehri S, Karimbeiki R, Ghasempour S, et al. The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta-analysis of randomized clinical trials. Phytother Res. 2020;34(2):329-339. View abstract.

Ngamjarus C, Pattanittum P, Somboonporn C. Roselle for hypertension in adults. Cochrane Database Syst Rev 2010:1:CD007894. View abstract.

Nwachukwu DC, Aneke E, Nwachukwu NZ, Obika LF, Nwagha UI, Eze AA. Effect of Hibiscus sabdariffaon blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: A comparative study with hydrochlorothiazide. Niger J Clin Pract. 2015 Nov-Dec;18(6):762-70. View abstract.

Sabzghabaee AM, Ataei E, Kelishadi R, Ghannadi A, Soltani R, Badri S, Shirani S. Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial. Mater Sociomed. 2013;25(2):76-9. View abstract.

Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015 Jun;33(6):1119-27. View abstract.

Showande SJ, Adegbolagun OM, Igbinoba SI, Fakeye TO. In vivo pharmacodynamic and pharmacokinetic interactions of Hibiscus sabdariffa calyces extracts with simvastatin. J Clin Pharm Ther. 2017;42(6):695-703. View abstract.

Souirti Z, Loukili M, Soudy ID, et al. Hibiscus sabdariffa increases hydroxocobalamin oral bioavailability and clinical efficacy in vitamin B(12) deficiency with neurological symptoms. Fundam Clin Pharmacol. 2016;30(6):568-576. View abstract.

Zhang B, Yue R, Wang Y, et al. Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis. Phytother Res. 2020;34(5):1083-1095. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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HIBISCUS SABDARIFFA - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Possibly Effective for

Side Effects

Special Precautions and Warnings

Interactions ?

Major Interaction

Chloroquine (Aralen) interacts with HIBISCUS SABDARIFFA

Moderate Interaction

Medications for diabetes (Antidiabetes drugs) interacts with HIBISCUS SABDARIFFA

Medications for high blood pressure (Antihypertensive drugs) interacts with HIBISCUS SABDARIFFA

Simvastatin (Zocor) interacts with HIBISCUS SABDARIFFA

Diclofenac (Voltaren, others) interacts with HIBISCUS SABDARIFFA

Losartan (Cozaar) interacts with HIBISCUS SABDARIFFA

Minor Interaction

Acetaminophen (Tylenol, others) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2A6 (CYP2A6) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2C8 (CYP2C8) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with HIBISCUS SABDARIFFA

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HIBISCUS SABDARIFFA

Dosing

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