LYSINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Lysine is an essential amino acid. The human body cannot make lysine, so it must be eaten in the diet. Sources include meat, fish, dairy, and eggs.

Lysine is a building block for making proteins in the body. It might also prevent the herpes virus from growing.

People use lysine for cold sores, canker sores, athletic performance, diabetes, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness ?

Possibly Effective for

Cold sores (herpes labialis). Taking lysine by mouth might help prevent and heal cold sores. It's not clear if applying it to the skin helps.

There is interest in using lysine for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Lysine is possibly safe for most people when taken in doses up to 3000 mg daily for up to one year. It can cause side effects such as stomach pain and diarrhea.

When applied to the skin: Lysine is possibly safe for most people when used short-term.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if lysine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Lysinuric protein intolerance: Lysine supplementation might cause diarrhea and stomach cramps in children who have this rare genetic disorder.

Interactions ?

Minor Interaction

Be watchful with this combination

Gastrointestinal agents (5-HT4 agonist) interacts with LYSINE
Lysine might reduce the effects of some gastrointestinal drugs called 5-HT4 agonists.

Dosing

Lysine has most often been used by adults in doses up to 3 grams daily for up to 1 year. It's also available in different topical products such as creams. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

REFERENCES:

[The effect of L-lysine added to diet on growth and development of normal children (author's transl)]. Zhonghua Yi.Xue.Za Zhi. 1982;62(1):11-12. View abstract.

Doraiswamy, T. R., Singh, N., and Daniel, V. A. Effects of supplementing ragi (Eleusine coracana) diets with lysine or leaf protein on the growth and nitrogen metabolism of children. Br.J.Nutr. 1969;23(4):737-743. View abstract.

Heinrichs, W., Fauth, U., Seufert, W., and Halmagyi, M. [Effect of L-lysine-induced amino acid imbalance on nitrogen balance in patients treated by total parenteral nutrition]. Infusionsther.Klin.Ernahr. 1987;14(6):252-255. View abstract.

Kagan, C. Letter: Lysine therapy for herpes simplex. Lancet 1-26-1974;1(7848):137. View abstract.

Matsuda, I., Arashima, S., Imanishi, Y., Yamamoto, J., Akaboshi, I., Shinozuka, S., and Nagata, N. Lysine intolerance in a variant form of citrullinemia. Pediatr.Res. 1979;13(10):1134-1136. View abstract.

Metges, C. C., Eberhard, M., and Petzke, K. J. Synthesis and absorption of intestinal microbial lysine in humans and non-ruminant animals and impact on human estimated average requirement of dietary lysine. Curr Opin Clin Nutr Metab Care 2006;9(1):37-41. View abstract.

Miller, C. S. and Foulke, C. N. Use of lysine in treating recurrent oral herpes simplex infections. Gen.Dent. 1984;32(6):490-493. View abstract.

Milman, N., Jessen, O., and Scheibel, J. [Lysine therapy of recurrent herpes simplex labialis]. Ugeskr.Laeger 10-22-1979;141(43):2960-2962. View abstract.

Milman, N., Scheibel, J., and Jessen, O. Failure of lysine treatment in recurrent herpes simplex labialis. Lancet 10-28-1978;2(8096):942. View abstract.

Pellett, P. L. and Ghosh, S. Lysine fortification: past, present, and future. Food Nutr.Bull. 2004;25(2):107-113. View abstract.

Peltola, K., Heinonen, O. J., Nanto-Salonen, K., Pulkki, K., and Simell, O. Oral lysine feeding in gyrate atrophy with hyperornithinaemia--a pilot study. J.Inherit.Metab Dis. 2000;23(4):305-307. View abstract.

Pereira, S. M., Begum, A., Jesudian, G., and Sundararaj, R. Lysine-supplemented wheat and growth of preschool children. Am.J.Clin.Nutr. 1969;22(5):606-611. View abstract.

Perfect, M. M., Bourne, N., Ebel, C., and Rosenthal, S. L. Use of complementary and alternative medicine for the treatment of genital herpes. Herpes. 2005;12(2):38-41. View abstract.

Smriga, M. and Torii, K. Metabolic interactions between restraint stress and L-lysine: the effect on urea cycle components. Amino.Acids 2003;24(4):435-437. View abstract.

Tomblin, F. A., Jr. and Lucas, K. H. Lysine for management of herpes labialis. Am.J.Health Syst.Pharm. 2-15-2001;58(4):298-300, 304. View abstract.

Torricelli, P., Fini, M., Giavaresi, G., Giardino, R., Gnudi, S., Nicolini, A., and Carpi, A. L-arginine and L-lysine stimulation on cultured human osteoblasts. Biomed.Pharmacother. 2002;56(10):492-497. View abstract.

Vianey-Liaud, C., Divry, P., Poinas, C., and Mathieu, M. [Lysine metabolism in man]. Ann.Biol.Clin.(Paris) 1991;49(1):18-26. View abstract.

Walther, F., Heine, W., Richter, I., and Wutzke, K. D. [Resorption and metabolic utilization of D-[alpha-15N]lysine and L-[alpha-15N]lysine after oral administration, with special reference to the metabolism of intestinal bacteria]. Biomed.Biochim.Acta 1987;46(11):803-808. View abstract.

Williams, M. H. Facts and fallacies of purported ergogenic amino acid supplements. Clin Sports Med 1999;18(3):633-649. View abstract.

Civitelli R, Villareal DT, Agnusdei D, et al. Dietary L-lysine and calcium metabolism in humans. Nutr 1992;8:400-5. View abstract.

Connor JM. Our customers are our enemies: The lysine cartel of 1992-1995. Rev Indust Org. 2001;18:5-21.

DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. View abstract.

Felzani G, , Spoletini I, , Convento A, , Di Lorenzo B, , Rossi P, , Miceli M, , Rosano G. Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients. Adv Ther. 2011 May;28(5):439-45. View abstract.

Flodin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am Coll Nutr 1997;16:7-12. View abstract.

Griffith RS, DeLong DC, Nelson JD. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy 1981;27:209-13. View abstract.

Griffith RS, Norins A, Kagan C. A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica 1978;156:257-67. View abstract.

Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. View abstract.

Hall SL, Greendale GA. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int 1998;63:183-9. View abstract.

Hlais S, , Reslan DR, , Sarieddine HK, , Nasreddine L, , Taan G, , Azar S, , Obeid OA. Effect of lysine, , vitamin B(6), , and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, , open-label, , randomized, , placebo-controlled trial. Clin Ther. 2012 Aug;34(8):1674-82. View abstract.

Krajcovicova-Kudlackova M, , Babinska K, , Valachovicova M. Health benefits and risks of plant proteins. Bratisl Lek Listy. 2005;106(6-7):231-4. View abstract.

Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. View abstract.

Lukkarinen M, Näntö-Salonen K, Pulkki K, Aalto M, Simell O. Oral supplementation corrects plasma lysine concentrations in lysinuric protein intolerance. Metabolism. 2003 Jul;52(7):935-8. View abstract.

McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73. View abstract.

Messina V. Nutritional and health benefits of dried beans. Am J Clin Nutr. 2014 Jul;100 Suppl 1:437S-42S. View abstract.

Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7. View abstract.

Natarajan Sulochana K., Lakshmi, S., Punitham, R., Arokiasamy, T., Sukumar, B., and Ramakrishnan, S. Effect of oral supplementation of free amino acids in type 2 diabetic patients-- a pilot clinical trial. Med Sci Monit. 2002;8(3):CR131-CR137. View abstract.

Rajantie J, Simell O, Rapola J, Perheentupa J. Lysinuric protein intolerance: a two-year trial of dietary supplementation therapy with citrulline and lysine. J Pediatr. 1980 Dec;97(6):927-32. View abstract.

Shashikumara S, Jayaraman V, Chikkegowda P, Lingaiah DC, Kalal BS. Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study. Int J Physiol Pathophysiol Pharmacol 2023;15(3):88-97. View abstract.

Singh BB, Udani J, Vinjamury Sp, et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev 2005;10:123-7. View abstract.

Smriga M, Ghosh S, Mouneimne Y, et al. Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proc.Natl.Acad.Sci.U.S.A 6-1-2004;101(22):8285-8288. View abstract.

Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5. View abstract.

Sulochana KN, Rajesh M, Ramakrishnan S. Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine. Indian J Biochem Biophys. 2001 Oct;38(5):331. View abstract.

Sun F, Chao L, Zhang J, Pan X. Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short stature. Growth Horm IGF Res 2023;69-70:101535. View abstract.

Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. View abstract.

Unni US, , Raj T, , Sambashivaiah S, , Kuriyan R, , Uthappa S, , Vaz M, , Regan MM, , Kurpad AV. The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, , insulin sensitivity and leucine kinetics in young men. Clin Nutr. 2012 Dec;31(6):903-10. View abstract.

Vuvor F, Mohammed H, Ndanu T, Harrison O. Effect of lysine supplementation on hypertensive men and women in selected peri-urban community in Ghana. BMC Nutr. 2017 Jul 27;3:67. doi: 10.1186/s40795-017-0187-6. View abstract.

Walsh DE, Griffith RS, and Behforooz A. Subjective response to lysine in the therapy of herpes simplex. J.Antimicrob.Chemother. 1983;12(5):489-496. View abstract.

Wass C, , Klamer D, , Katsarogiannis E, , Pålsson E, , Svensson L, , Fejgin K, , Bogren IB, , Engel JA, , Rembeck B. L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, , randomized, , cross-over pilot study. BMC Med. 2011 Apr 18;9:40. View abstract.

Wright EF. Clinical effectiveness of lysine in treating recurrent aphthous ulcers and herpes labialis. Gen.Dent. 1994;42(1):40-42. View abstract.

Wu G. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. J Anim Sci Biotechnol. 2014 Jun 14;5(1):34. View abstract.

Zeinoddini A, , Ahadi M, , Farokhnia M, , Rezaei F, , Tabrizi M, , Akhondzadeh S. L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, , placebo-controlled, , randomized trial. J Psychiatr Res. 2014 Dec;59:125-31. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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