Acute hepatic porphyria (AHP) is one of a group of disorders that are triggered by a buildup of pigments called porphyrins in your liver and elsewhere. The disorder can cause nerve problems and other symptoms.
There’s no cure, but treatment can help you feel better.
What Causes Acute Hepatic Porphyria?
Porphyrins are natural chemicals in your body. They are made by your body when it creates something called heme.
Heme is part of hemoglobin -- the protein in red blood cells that carries oxygen from your lungs to the rest of your body. It's critical for many body functions, like in the liver and muscles. It's also found in bone marrow.
When heme is made in your bone marrow and liver, eight enzymes are needed for the process to work properly. If there's a shortage in one of those enzymes, your levels of porphyrins could go up. Which of the eight enzymes is low and where the porphyrins are in your body determine which type of porphyria you have. With acute hepatic porphyria, there is a buildup of porphyrins in your liver.
That can cause problems, usually in your skin or with your nerves. You could also have:
- Dark urine
- Sensitive skin
- Belly pain
- Nausea
- Seizures
An attack usually starts with severe stomach pain and can last for days. You'll usually need to go to the hospital for treatment.
Who Gets It
In most cases, porphyria is inherited, meaning you have the genes for the disease passed down from your parents.
But just because you have the genes doesn’t mean you'll have symptoms. Most people who have the gene for the disease never show signs of AHP.
Attacks can be triggered by other things, including:
- Specific drugs, including barbiturates, tranquilizers, birth control pills, and sedatives
- Drinking alcohol
- Smoking
- Dieting or fasting
- Stress
- Specific dietary choices
- Fasting
A well-rounded diet is important if you have this disorder. Consider consulting a nutritionist or behavioral specialist to help you maintain healthy habits.
