Uses

What is Nubeqa used for?

Nubeqa (darolutamide) is commonly used to treat prostate cancer.

Learn more about Nubeqa for Prostate Cancer.

Nubeqa may also be used for other conditions as determined by your healthcare provider.

How does Nubeqa work (mechanism of action)?

Prostate cancer cells need certain hormones, called androgens, to grow. Nubeqa works by blocking the effects of androgens, which can help slow the growth of prostate cancer. 

How is Nubeqa supplied (dosage forms)?

Nubeqa is available as 300 mg oral tablets that are swallowed.

How should I store Nubeqa?

Nubeqa should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store it in a cool, dry place and keep the bottle tightly closed.

Side Effects

What are the most common side effects of Nubeqa?

The most common side effects of Nubeqa are listed below. These side effects may vary depending on the type of prostate cancer being treated. Tell your healthcare provider if you have any of these side effects that bother you.

There may be other side effects of Nubeqa that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Nubeqa?

While less common, the most serious side effects of Nubeqa are described below, along with what to do if they happen.

Seizures. Some people who have taken Nubeqa have reported having seizures. There are many different types of seizures and some of them are not easy to recognize. Call your healthcare provider if you have any of the following signs that a seizure is happening or could happen.

  • Muscle twitching, jerking, spasms, tremors, or other uncontrolled movements
  • Stiffening of your arms and legs
  • Feeling anxious, nervous, confused, or a sense of dread
  • Feeling dizzy or lightheaded
  • Falling or losing consciousness

Heart Disease. Taking Nubeqa may increase the risk of ischemic heart disease, which is when blood flow to the heart is reduced. This could lead to a heart attack or stroke. You may have a higher chance of this side effect if you already have certain conditions, such as high blood pressure, diabetes, or high cholesterol. Get emergency help if you have any of the following symptoms.

  • Chest pain or pressure
  • Fast or abnormal heartbeat
  • Trouble breathing
  • Pain in your back, jaw, throat, or arm
  • Sweating, upset stomach, vomiting, or dizziness
  • Sudden weakness on one side of your body
  • Sudden and severe headache
  • Slurred speech or trouble understanding speech  

Severe Allergic Reactions. Nubeqa may cause allergic reactions, which can be serious. Stop taking Nubeqa and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Nubeqa?

Allergies to Ingredients. People who are allergic to any of the following should not take Nubeqa.

  • Nubeqa
  • Darolutamide
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Nubeqa.

What should I know about Nubeqa before taking it?

Do not take Nubeqa unless it has been prescribed to you by a healthcare provider. Take it as prescribed. 

Do not share Nubeqa with other people, even if they have the same condition as you. It may harm them.

Keep Nubeqa out of the reach of children.

Take Nubeqa with food. Swallow the tablets whole.

Nubeqa can cause harm to an unborn baby. If your partner is pregnant or able to become pregnant, use effective birth control (such as condoms) while taking Nubeqa and for one week after your last dose. 

Nubeqa may affect your ability to father a child. Talk with your healthcare provider if you have concerns about this.

What should I tell my healthcare provider before taking Nubeqa?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Nubeqa is right for you.

In particular, make sure that you discuss any of the following.

Other Medicines and Supplements. Nubeqa may interact with other medicines and supplements. Before taking Nubeqa, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Heart problems
  • High blood pressure
  • Diabetes
  • High cholesterol or other lipid problems
  • Brain problems, such as seizures, brain injury, stroke, or brain tumors
  • Kidney problems
  • Liver problems

Pregnancy. People who can become pregnant are not usually prescribed Nubeqa. Nubeqa can cause harm to an unborn baby and should not be taken while pregnant. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. People who can breastfeed are not usually prescribed Nubeqa. It is not known if Nubeqa passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Nubeqa?

For more information about Nubeqa, you can visit the manufacturer’s website at www.nubeqa-us.com or call them at 888-842-2937.

Interactions

Does Nubeqa interact with foods or drinks?

There are no known interactions between Nubeqa and foods or drinks. You should take Nubeqa with food.

It is unknown if drinking alcohol will affect Nubeqa.

Does Nubeqa interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are taking any of the following before taking Nubeqa.

  • Itraconazole (Sporanox, Tolsura), which is a medicine used for a fungal infection
  • Rifampin, which is a medicine commonly used to treat an infection called tuberculosis
  • Rosuvastatin (Crestor), which is a medicine used to lower cholesterol

Many other medicines may alter the blood levels of Nubeqa, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken. 

This may not be a complete list of medicines that can interact with Nubeqa. Always check with your healthcare provider.

Does Nubeqa (darolutamide) interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally take too much Nubeqa?

If you or someone else has taken too much Nubeqa, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Nubeqa?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses. 

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