Uses
What is Reyvow used for?
Reyvow is commonly used for the treatment of migraine with or without aura. An aura may occur before or during a migraine attack, and can include sensory problems like seeing flashing lights or zigzag lines, having trouble speaking, or experiencing a tingling sensation.
Reyvow may also be used for other conditions as determined by your healthcare provider.
How does Reyvow work (mechanism of action)?
Reyvow is part of a class of medicines known as serotonin agonists. The way it works is not completely understood. However, it is thought to work by attaching to and activating a receptor in the brain called the 5-HT1F receptor, helping to relieve migraine symptoms.
How is Reyvow supplied (dosage forms)?
Reyvow is available in the following dosage forms that are taken by mouth.
- 50 mg oral tablets
- 100 mg oral tablets
- 200 mg oral tablets
How should I store Reyvow?
Reyvow should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Side Effects
What are the most common side effects of Reyvow?
The most common side effects of Reyvow are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Dizziness
- Sleepiness
- Numbness and tingling
- Feeling unusually tired
There may be other side effects of Reyvow that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Reyvow?
While less common, the most serious side effects of Reyvow are described below, along with what to do if they happen.
Severe Allergic Reactions. Reyvow may cause allergic reactions, which can be serious. Stop taking Reyvow and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Driving Impairment. Reyvow can significantly affect your ability to drive, as well as your ability to assess your driving ability and degree of impairment. This effect can last up to 8 hours after taking a dose of medicine. Do not participate in any activities that require complete mental alertness, including driving or operating machinery, for at least 8 hours after you take a dose of Reyvow. If you cannot follow this advice, do not take Reyvow.
Central Nervous System Depression. Reyvow can cause central nervous system (CNS) depression. This refers to a slowing down of brain and spinal cord activity. CNS depression can cause symptoms of dizziness, extreme drowsiness, decreased heart rate, and slowed breathing. If you drink alcohol or take other CNS depressants (any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety), you should talk to your healthcare provider about the safety of Reyvow.
Serotonin Syndrome. Serotonin syndrome is when there is too much of a substance called serotonin in your body. Reyvow can cause serotonin syndrome when it is taken alone or with other medicines that affect serotonin. This condition can be life-threatening. Get emergency help if you have any of the following symptoms of serotonin syndrome.
- Sweating, fever, or flushing
- Confusion
- Feeling agitated or restless
- Seeing or hearing unusual things
- Dizziness
- Fast or racing heartbeat
- Nausea, vomiting, or diarrhea
- Muscle twitching, stiffness, or tremor
- Seizures
Medication Overuse Headache. Taking Reyvow more often than prescribed may cause headaches to worsen or increase in frequency, which is known as medication overuse headache or rebound headache. Notify your healthcare provider if you have more frequent migraine attacks.
Warnings & Precautions
Who should not use Reyvow?
Allergies to Ingredients. People who are allergic to any of the following should not take Reyvow.
- Lasmiditan
- Reyvow
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Reyvow.
Liver Problems. Reyvow should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.
What should I know about Reyvow before using it?
Do not take Reyvow unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Reyvow with other people, even if they have the same condition as you. It may harm them.
Keep Reyvow out of the reach of children. Reyvow is a controlled substance because it can be misused or lead to dependence. Store Reyvow in a safe place to protect it from theft. It is illegal to sell or give away this medicine.
Do not chew, split, or crush Reyvow tablets.
Reyvow can affect your alertness or coordination. Do not drive, operate machinery, or perform any tasks that require complete mental alertness, for at least 8 hours after you take Reyvow.
People who are 65 and older can be at greater risk for some side effects from Reyvow. Talk to your healthcare provider about your risks if you are in this age group.
You should keep a journal (or use a mobile app) to keep track of migraine attacks, along with when you take Reyvow. This will help you and your healthcare provider understand how well Reyvow works for you.
What should I tell my healthcare provider before using Reyvow?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Reyvow is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Liver problems
- High blood pressure
- Low heart rate
- History of substance use disorder (including alcohol, prescription medicines, or street drugs)
Pregnancy. It is not known if or how Reyvow could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take Reyvow while you are pregnant or trying to get pregnant. If you become pregnant while taking Reyvow, you can register for the Migraine Pregnancy Registry by calling 833-464-4724 or at www.migrainepregnancyregistry.com. This registry collects safety information about the use of migraine medicines during pregnancy.
Breastfeeding. It is not known if Reyvow passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.
How can I get more information about Reyvow?
For more information about Reyvow, you can visit the manufacturer’s website at reyvow.lilly.com or call them at 833-REYVOW1 (833-739-8691).
Interactions
Does Reyvow interact with foods or drinks?
There are no known interactions between Reyvow and foods or drinks.
You should not drink alcohol while taking Reyvow. The risk of drowsiness and dizziness may be increased if you drink alcohol while taking Reyvow. Also, alcohol can trigger migraine attacks in some people. Consult your healthcare provider for more information and medical advice.
Does Reyvow interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Reyvow.
- Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety
- A selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), which are medicines commonly used for anxiety and depression
- A monoamine oxidase inhibitor (MAOI) [within the past 2 weeks], which is a medicine usually used for depression or Parkinson’s disease
- A tricyclic antidepressant, such as amitriptyline, nortriptyline, or protriptyline, even if it is not used for depression
- St. John’s wort, which is a supplement that may be used to treat depression
- Trazodone, which is a medicine commonly used for depression
- Dextromethorphan, which is a medicine used for cough, and is found in many cough and cold products
- Propranolol (Inderal LA), which is a medicine that may be used for certain heart conditions or to reduce blood pressure
- Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
Some other medicines may alter the blood levels of Reyvow, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Reyvow. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Reyvow?
If you or someone else has used too much Reyvow, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Reyvow?
Reyvow is meant to be used only when needed. Take it as your healthcare provider recommends. Do not take double or extra doses.
Are you currently using Reyvow (lasmiditan)?
This survey is being conducted by the WebMD marketing sciences department.