Uses
Amivantamab is used to treat a certain type of lung cancer (non-small cell lung cancer - NSCLC). It works by slowing or stopping the growth of cancer cells.
How to use Rybrevant Vial
Read the Patient Information Leaflet if available from your pharmacist before you start using amivantamab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is given by injection into a vein by a health care professional. It is given as directed by your doctor. The dosage and treatment schedule are based on your medical condition, weight, and response to treatment.
Infusion reactions may happen during the infusion of this drug. Your doctor may prescribe other medications (such as acetaminophen, diphenhydramine, dexamethasone) before each treatment to help prevent these side effects. Tell your doctor right away if you have symptoms of infusion reactions such as nausea, vomiting, fever, chills, flushing, shortness of breath, chest pain, or dizziness.
Side Effects
See also How to Use section.
Dry skin, tiredness, muscle/joint pain, nausea/vomiting, diarrhea or constipation, mouth sores, abdominal pain, decreased appetite, headache, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
An alcohol-free moisturizer may help to reduce the risk of dry skin and other skin problems.
People using this medication may have serious side effects. However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.
Tell your doctor right away if you have any serious side effects, including: signs of lung disease (such as fever, new or worsening cough/shortness of breath), vision changes (such as blurred vision), itchy/dry eyes, eye pain/redness, swelling ankles/feet/hands, numbness/tingling of arms/legs, redness/swelling/pain around the nails, easy bleeding/bruising.
When used with a certain medication (lazertinib), amivantamab may cause blood clots in the lungs or legs. Your doctor should prescribe an anticoagulant while you are taking the 2 medications together, especially during the first 4 months of treatment. Get medical help right away if any of these side effects occur: chest pain, trouble breathing, pain/swelling/warmth in the groin/calf.
This medication can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before receiving amivantamab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
This medication may make you more sensitive to the sun. Limit your time in the sun while you receive this medication and for 2 months after stopping treatment. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using amivantamab. Amivantamab may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Ask about reliable forms of birth control while using this medication and for 3 months after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug and for 3 months after the last dose. Consult your doctor before breastfeeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669.
Lab and/or medical tests (such as kidney/liver function, blood mineral levels, blood glucose levels) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.
Not applicable. This medication is given in a hospital or clinic and will not be stored at home.
Images
Are you currently using Rybrevant Vial?
This survey is being conducted by the WebMD marketing sciences department.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.