Uses
What is Zoryve used for?
Zoryve (roflumilast) is commonly used to treat the following conditions.
- Plaque psoriasis, a skin condition that can cause an itchy, painful rash with raised red patches of skin
- Atopic dermatitis, a skin condition that can cause an itchy, dry rash with scaly patches or blisters
Zoryve foam is commonly used to treat seborrheic dermatitis, a skin condition that can cause an itchy rash with flaky skin.
Zoryve may also be used for other conditions as determined by your healthcare provider.
Roflumilast is also available as an oral tablet that is taken by mouth. See Roflumilast for more information.
How does Zoryve work (mechanism of action)?
Zoryve belongs to a group of medicines called phosphodiesterase-4 (PDE4) inhibitors. It is believed to increase the amount of a specific chemical in the body that can help reduce inflammation and pain.
How is Zoryve supplied (dosage forms)?
Zoryve is available in the following dosage forms that are applied to the skin.
- 0.15% topical cream
- 0.3% topical cream
- 0.3% topical foam
How should I store Zoryve?
Topical Cream. Zoryve cream should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Topical Foam. Zoryve foam should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Store in an upright position. Do not freeze. Do not puncture the container or expose it to heat (temperature above 120 F or 49 C).
Side Effects
What are the most common side effects of Zoryve?
The most common side effects of Zoryve are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
Topical Cream (Used for Plaque Psoriasis).
- Diarrhea
- Headache
- Trouble sleeping
- Nausea
- Pain where the product is applied
- Infection in the nose or throat, sore throat, or common cold symptoms
- Kidney or bladder infection
Topical Cream (Used for Atopic Dermatitis).
- Headache
- Nausea
- Pain where the product is applied
- Diarrhea
- Vomiting
Topical Foam.
- Infection in the nose or throat, sore throat, or common cold symptoms
- Nausea
- Headache
There may be other side effects of Zoryve that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Zoryve?
While less common, the most serious side effects of Zoryve are described below, along with what to do if they happen.
Severe Allergic Reactions. Zoryve may cause allergic reactions, which can be serious. Stop using Zoryve and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Warnings & Precautions
Who should not use Zoryve?
Allergies to Ingredients. People who are allergic to any of the following should not use Zoryve.
- Roflumilast
- Zoryve
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Zoryve.
Liver Problems. Zoryve should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to use this medicine.
What should I know about Zoryve before using it?
Do not use Zoryve unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
Do not share Zoryve with other people, even if they have the same condition as you. It may harm them.
Keep Zoryve out of the reach of children.
Zoryve is for use on the skin only. It should not be used on other areas of the body such as your eyes, mouth, or vagina. Zoryve foam should be used on dry skin.
Wash your hands after applying Zoryve, unless the prescribed treatment area is your hand(s).
If you are using Zoryve foam, shake the can well before each use.
Avoid fire or flame (including smoking) shortly after applying Zoryve foam. The contents are flammable.
What should I tell my healthcare provider before using Zoryve?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Zoryve is right for you.
In particular, make sure that you discuss any of the following.
Liver Problems. Tell your healthcare provider if you have any known or suspected liver problems.
Pregnancy. It is not known if or how Zoryve could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.
Breastfeeding. It is not known if Zoryve passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Zoryve while breastfeeding. If you are using Zoryve while breastfeeding, do not apply Zoryve directly to the nipple or areola that comes in direct contact with your baby’s mouth. If Zoryve is applied to your chest area, make sure the treated skin area does not come in direct contact with the baby.
How can I get more information about Zoryve?
For more information about Zoryve, you can visit the manufacturer’s website at www.zoryve.com or call them at 805-418-5006.
Interactions
Does Zoryve interact with foods or drinks?
There are no known interactions between Zoryve and foods or drinks.
It is unknown if drinking alcohol will affect Zoryve.
Does Zoryve interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before using Zoryve.
- A birth control pill that contains ethinyl estradiol
- Erythromycin (Ery-Tab and others), which is a medicine used for bacterial infections
- Ketoconazole, which is a medicine used for fungal infections
- Fluvoxamine, which is a medicine commonly used for anxiety and depression
- Cimetidine (Tagamet HB), which is a medicine used for heartburn
Many other medicines may alter the blood levels of roflumilast (the active drug of Zoryve). Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Zoryve. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Zoryve?
If you or someone else has used too much Zoryve, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Zoryve?
If you miss your scheduled application of Zoryve, apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed application and follow the original schedule. Do not apply Zoryve more often than prescribed.