Uses
What is Nemluvio used for?
Nemluvio (nemolizumab-ilto) is commonly used to treat a skin condition that causes a persistent, intense itch called prurigo nodularis.
Nemluvio may also be used for other conditions as determined by your healthcare provider.
How does Nemluvio work (mechanism of action)?
Nemluvio works by blocking the effect of a substance called interleukin-31 (IL-31). This substance is normally made by your body and is part of your body’s response to itching and inflammation. Blocking this substance can help treat the symptoms of prurigo nodularis.
How is Nemluvio supplied (dosage forms)?
Nemluvio is available as a 30 mg/0.49 mL solution for injection, single-dose prefilled pen that is injected under the skin.
How should I store Nemluvio?
Store Nemluvio in the original carton in a refrigerator, between 36 F to 46 F (2 C to 8 C). Do not freeze Nemluvio.
You can store Nemluvio for up to 90 days at room temperature, between 68 F to 77 F (20 C to 25 C) in the original carton to protect it from light.
Do not store Nemluvio above 77 F (25 C) or in direct sunlight. Throw Nemluvio away if it was heated, frozen, or after 90 days if kept at room temperature.
Side Effects
What are the most common side effects of Nemluvio?
The most common side effects of Nemluvio are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Headache
- Red, itchy rashes on the skin, called atopic dermatitis or eczema
- Scattered circular patches on skin, called nummular eczema
There may be other side effects of Nemluvio that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Nemluvio?
While less common, the most serious side effects of Nemluvio are described below, along with what to do if they happen.
Severe Allergic Reactions. Nemluvio may cause allergic reactions, which can be serious. Stop using Nemluvio and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Warnings & Precautions
Who should not use Nemluvio?
Allergies to Ingredients. People who are allergic to any of the following should not use Nemluvio.
- Nemluvio
- Nemolizumab-ilto
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Nemluvio.
What should I know about Nemluvio before using it?
Do not use Nemluvio unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
Do not share Nemluvio with other people, even if they have the same condition as you. It may harm them.
Keep Nemluvio out of the reach of children. Since this medicine may be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.
This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Nemluvio. If you have any questions, talk to your healthcare provider.
If you store Nemluvio in the refrigerator, make sure to take it out of the refrigerator 30 to 45 minutes before administration. This way it can reach room temperature before injecting under the skin. If the medicine is injected while cold, it might cause pain at the injection site.
Do not warm Nemluvio in the microwave, direct sunlight, hot liquid, or any other heat source. This can damage the medicine.
If you store Nemluvio at room temperature, write the date on the pen when you took it out of the refrigerator. It is good for 90 days at room temperature.
Look at the powder and liquid in the pen chamber before using. Do not use Nemluvio if the powder is not white or if the liquid is cloudy or contains visible particles.
Make sure you mix (reconstitute) Nemluvio before using it. Inspect the mixed product before injecting Nemluvio. The solution should be clear, colorless, or slightly yellow. Do not use Nemluvio if the powder is not completely dissolved, or if you see discoloration or floating particles in the solution.
Once you mix Nemluvio, make sure to inject the dose within 4 hours. If it has been longer than 4 hours, throw away the mixed Nemluvio and use a new pen.
Inject Nemluvio into your front upper thigh or abdomen. Avoid injecting too close to the belly button.
Do not inject Nemluvio into your upper arm. This should only be done by your healthcare professional or caregiver.
Use a different injection site each time you use Nemluvio. Do not give the injection into tender areas, bruises, scars, red skin, or stretch marks. If you need to use more than one pen to get your prescribed dose, do not use the same injection site for the second pen. Inject the medicine at least 1 inch away from the first injection site.
Throw away Nemluvio after you give yourself a dose, even if there is medicine left in the pen. Each pen is good for just one use. Dispose Nemluvio in a sharps container or in a household container made of heavy-duty plastic that is able to close tightly and is puncture- and leak-resistant.
Do not use Nemluvio if the pen is broken, damaged, or cracked.
What should I tell my healthcare provider before using Nemluvio?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Nemluvio is right for you.
In particular, make sure that you discuss any of the following.
Vaccines. You should not receive any live vaccines right before or while using Nemluvio. Tell your healthcare provider if you have recently received a live vaccine or have any scheduled.
Pregnancy. It is not known if or how Nemluvio could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.
Breastfeeding. It is not known if Nemluvio passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Nemluvio while breastfeeding.
How can I get more information about Nemluvio?
For more information about Nemluvio, you can visit the manufacturer’s website at www.nemluvio.com or call them at 866-735-4137.
Interactions
Does Nemluvio interact with foods or drinks?
There are no known interactions between Nemluvio and foods or drinks.
It is unknown if drinking alcohol will affect Nemluvio.
Does Nemluvio interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before using Nemluvio.
- Warfarin, which is a blood thinner
- Cyclosporine, which is a medicine that suppresses your immune system
Nemluvio may alter the blood levels of some other medicines. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Nemluvio. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Nemluvio?
If you or someone else has used too much Nemluvio, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Nemluvio?
If you miss a dose of Nemluvio, inject the dose as soon as you remember. Inject your next scheduled dose at your regular time.
Are you currently using Nemluvio (nemolizumab-ilto)?
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