Uses
What is Lazcluze used for?
Lazcluze (lazertinib) is commonly used to treat certain types of non-small cell lung cancer (NSCLC).
Lazcluze may also be used for other conditions as determined by your healthcare provider.
How does Lazcluze work (mechanism of action)?
Lazcluze works by targeting a specific protein called epidermal growth factor receptor (EGFR), which is involved in the growth of some cancer cells. Lazcluze targets certain problems in EGFR genes, which makes it work against cancer cells that have this problem.
How is Lazcluze supplied (dosage forms)?
Lazcluze is available in the following dosage forms that are taken by mouth.
- 80 mg oral tablets
- 240 mg oral tablets
How should I store Lazcluze?
Lazcluze should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Side Effects
What are the most common side effects of Lazcluze?
The most common side effects of Lazcluze are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Rash
- Itching
- Infected skin around your nail
- Mouth sores
- Muscle or joint pain
- Fluid retention
- Numbness, tingling, or burning in your arms, feet, or face
- Tiredness
- Diarrhea, constipation, or nausea
- Decreased appetite
- COVID-19 infection
- Bleeding
- Blood clots (see below)
- Eye problems (see below)
There may be other side effects of Lazcluze that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Lazcluze?
While less common, the most serious side effects of Lazcluze are described below, along with what to do if they happen.
Severe Allergic Reactions. Lazcluze may cause allergic reactions, which can be serious. Stop taking Lazcluze and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Blood Clots. Lazcluze may cause a blood clot in your veins, called venous thromboembolism (VTE). A blood clot that travels to your lungs is called a pulmonary embolism. A blood clot in your legs or arms is called a deep venous thrombosis. Take any medicine that your healthcare provider recommends to prevent a blood clot. Get emergency help right away if you have any of the following signs of a blood clot.
- Chest pain or pressure
- Fast or abnormal heartbeat
- Fast breathing or shortness of breath
- Pain, swelling, or tenderness in your arm or leg
- Red or warm skin in your arm or leg
Lung Problems. Lazcluze may cause serious lung conditions called interstitial lung disease (ILD) or pneumonitis. The symptoms of lung problems caused by Lazcluze may be similar to the symptoms of lung cancer. Call your healthcare provider right away if you have new or worsening symptoms of lung problems such as the following.
- Shortness of breath
- Cough
- Fever
- Weight loss
- Loss of appetite
Skin Problems. Lazcluze may cause serious skin problems, such as severe rash. Your healthcare provider may recommend other medicines to prevent skin problems during treatment with Lazcluze. Tell your healthcare provider if you have any of the following symptoms of skin problems.
- Rash
- Skin redness
- Raised bumps on your skin that look like acne
- Itching
- Dry skin
Eye Problems. Lazcluze may cause serious eye problems such as keratitis, which is inflammation of a part of your eye called the cornea. If you have eye problems during treatment with Lazcluze, your healthcare provider may send you to an eye specialist, called an ophthalmologist. Do not use contact lenses until you are checked by your healthcare provider. Tell your healthcare provider right away if you have any of the following symptoms.
- Eye pain, burning, or irritation
- Eye redness
- Vision changes such as loss of vision or blurry vision
- Lots of tears or discharge from your eye
- Swelling of your eye
- Eyes sensitive to light
Warnings & Precautions
Who should not use Lazcluze?
Allergies to Ingredients. People who are allergic to any of the following should not take Lazcluze.
- Lazcluze
- Lazertinib
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Lazcluze.
What should I know about Lazcluze before using it?
Do not take Lazcluze unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Lazcluze with other people, even if they have the same condition as you. It may harm them.
Keep Lazcluze out of the reach of children.
Swallow Lazcluze tablets whole. Do not chew, cut, or crush Lazcluze.
Use an alcohol-free moisturizing cream to reduce your risk of skin problems caused by Lazcluze.
To reduce your risk of skin problems during treatment with Lazcluze, limit your sun exposure during and for 2 months after treatment with Lazcluze. Use sunscreen and wear a hat and clothes that cover your skin if you need to be in the sunlight.
If you can become pregnant or if you are a male with a female partner who can become pregnant, use effective birth control while you are taking Lazcluze and for 3 weeks after your last dose. Talk to your healthcare provider about your birth control options.
Lazcluze may affect your ability to become pregnant or get your partner pregnant. Talk to your healthcare provider if you have any concerns.
If you have certain serious side effects, your healthcare provider may need to lower your dose or stop your treatment with Lazcluze.
Keep all of your appointments to have your blood checked. Your healthcare provider may need to lower your dose or stop Lazcluze based on the results.
What should I tell my healthcare provider before using Lazcluze?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Lazcluze is right for you.
In particular, make sure that you discuss any of the following.
History of Lung or Breathing Problems. Tell your healthcare provider if you have had any lung or breathing problems.
Other Medicines and Supplements. Lazcluze may interact with other medicines and supplements. Before taking Lazcluze, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. Lazcluze may cause harm to an unborn baby. If you can become pregnant, your healthcare provider should verify you are not pregnant before starting treatment. If you or your partner can become pregnant, use effective birth control while you are taking Lazcluze and for 3 weeks after your last dose. Talk to your healthcare provider about your birth control options. Tell your healthcare provider if you are or plan to become pregnant.
Breastfeeding. Do not breastfeed during or for 3 weeks after your last dose of Lazcluze. It is not known if Lazcluze passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.
How can I get more information about Lazcluze?
For more information about Lazcluze, you can visit the manufacturer’s website at www.janssenscience.com/products/lazcluze or call them at 800-JANSSEN (800-526-7736).
Interactions
Does Lazcluze interact with foods or drinks?
There are no known interactions between Lazcluze and foods or drinks.
There are no known interactions between Lazcluze and alcohol.
Does Lazcluze interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Lazcluze.
- Efavirenz, which is a medicine for HIV or AIDS
- Rifampin, which is a medicine commonly used to treat an infection called tuberculosis
Many other medicines may alter the blood levels of Lazcluze, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Lazcluze. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Lazcluze?
If you or someone else has used too much Lazcluze, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Lazcluze?
If you miss a dose within 12 hours of the usual time, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and only take the next dose at the usual time. Do not take double or extra doses, including if you vomit a dose.
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