Uses
What is Cobenfy used for?
Cobenfy (xanomeline/trospium) is commonly used to treat schizophrenia. Schizophrenia is a mental health disorder that affects a person's thinking, actions, emotions, perception of reality, and how they relate to others.
Cobenfy may also be used for other conditions as determined by your healthcare provider.
How does Cobenfy work (mechanism of action)?
Dopamine and acetylcholine are important chemicals in your brain. Other drugs for schizophrenia target dopamine receptors. Cobenfy may work to reduce symptoms of schizophrenia by targeting cholinergic receptors, where acetylcholine binds.
How is Cobenfy supplied (dosage forms)?
Cobenfy is available in the following dosage forms that are taken by mouth.
- 50 mg/20 mg oral capsules
- 100 mg/20 mg oral capsules
- 125 mg/30 mg oral capsules
How should I store Cobenfy?
Cobenfy should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Side Effects
What are the most common side effects of Cobenfy?
The most common side effects of Cobenfy are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Nausea, vomiting, diarrhea, or constipation
- High blood pressure
- Fast heart rate (see below)
- Stomach pain, upset stomach, or acid reflux
- Dizziness
There may be other side effects of Cobenfy that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Cobenfy?
While less common, the most serious side effects of Cobenfy are described below, along with what to do if they happen.
Severe Allergic Reactions. Cobenfy may cause allergic reactions, which can be serious. Stop taking Cobenfy and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat (angioedema)
- Trouble swallowing or throat tightness
- Hoarseness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Inability to Empty Bladder (Urinary Retention). Cobenfy might make it harder to empty your bladder, which can sometimes lead to a bladder infection. Your risk for urinary retention may be higher if you already have a blockage, you have an enlarged prostate, or you take other medicines for overactive bladder. Stop taking Cobenfy and call your healthcare provider right away or get emergency help if you have any of the following symptoms of urinary retention.
- Trouble peeing
- Trouble emptying your bladder when it is full
- Pain when you pee
- Peeing more often than usual
- A slow stream or drips rather than a normal stream when you pee
Slowed Stomach Emptying (Gastroparesis). Cobenfy may cause or worsen slowed movement of food from your stomach to your intestines, also called gastroparesis. You may be at higher risk for this if you have certain conditions, such as ulcerative colitis or myasthenia gravis. Call your healthcare provider right away if you have any of the following severe symptoms.
- Nausea, vomiting, or constipation
- Stomach pain or acid reflux
- Feeling full sooner than usual when eating
- Feeling bloated
Fast Heart Rate (Tachycardia). Cobenfy may cause your heart to beat fast. Tell your healthcare provider if you notice changes in your heart rate, such as a fast or pounding heartbeat.
Central Nervous System (CNS) Problems. Cobenfy can affect your central nervous system (CNS), which includes your brain and spinal cord. Call your healthcare provider right away if you have the following symptoms of CNS problems.
- DIzziness
- Sleepiness
- Confusion
- Seeing or hearing things that others do not see or hear, also called hallucinations
Warnings & Precautions
Who should not use Cobenfy?
Allergies to Ingredients. People who are allergic to any of the following should not take Cobenfy.
- Cobenfy
- Xanomeline
- Trospium chloride
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Cobenfy.
Liver Problems. Cobenfy should not be taken if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.
Inability to Empty Bladder (Urinary Retention). Cobenfy should not be taken if you have trouble emptying your bladder.
Glaucoma. Cobenfy should not be taken if you have increased pressure inside the eye (narrow-angle glaucoma) that is not being managed by your healthcare provider.
Slowed Stomach Emptying (Gastroparesis). Cobenfy should not be taken if you have slowed stomach emptying (gastroparesis).
What should I know about Cobenfy before using it?
Do not take Cobenfy unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Cobenfy with other people, even if they have the same condition as you. It may harm them.
Keep Cobenfy out of the reach of children.
Do not open Cobenfy capsules. They should be swallowed whole.
People who have kidney problems or who are 65 or older can be at greater risk for some side effects from Cobenfy. Talk to your healthcare provider about your risks if you are in this age group or if you have kidney problems.
Cobenfy can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Cobenfy affects you.
Your healthcare provider will likely check your heart rate (pulse) and lab tests prior to starting and while you are taking Cobenfy. It is important for you to keep all appointments, including those for lab tests, while taking Cobenfy.
What should I tell my healthcare provider before using Cobenfy?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Cobenfy is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Stomach or intestinal problems, including constipation, a blockage, or ulcerative colitis
- Prostate or bladder problems
- Myasthenia gravis
- Pancreas problems
- Kidney problems
Glaucoma. Cobenfy may increase pressure inside the eye and worsen narrow-angle glaucoma, which can lead to blindness. Tell your healthcare provider if you have glaucoma.
Bile Duct or Gallbladder Problems. Cobenfy may worsen bile duct or gallbladder problems. This can lead to gallstones (also called cholelithiasis), inflammation of the pancreas (also called pancreatitis), and liver problems. Tell your healthcare provider if you have ever had any of these problems.
Other Medicines and Supplements. Cobenfy may interact with other medicines and supplements. Before taking Cobenfy, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how Cobenfy could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take Cobenfy while you are pregnant or trying to get pregnant. If you become pregnant while taking Cobenfy, you can register with the National Pregnancy Registry for Atypical Antipsychotics by calling 866-961-2388 or at womensmentalhealth.org/research/pregnancyregistry/atypicalantipsychotic. This registry collects safety information about the use of medicines to treat psychiatric, mood or anxiety problems during pregnancy.
Breastfeeding. It is not known if Cobenfy passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Cobenfy while breastfeeding.
How can I get more information about Cobenfy?
For more information about Cobenfy, you can visit the manufacturer’s website at www.cobenfy.com or call them at 877-262-3639.
Interactions
Does Cobenfy interact with foods or drinks?
Cobenfy should be taken on an empty stomach. Avoid taking Cobenfy within 1 hour before meals or within 2 hours after meals. Taking Cobenfy with food may change the blood levels of the medicine and how it works for you.
It is unknown if drinking alcohol will affect Cobenfy. The risk of dizziness may be increased if you drink alcohol while taking Cobenfy.
Does Cobenfy interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using an anticholinergic medicine, which includes antihistamines and medicines commonly used for overactive bladder, Parkinson’s disease, or stomach problems before taking Cobenfy.
Many other medicines may alter the blood levels of Cobenfy, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Cobenfy. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Cobenfy?
If you or someone else has used too much Cobenfy, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Cobenfy?
If you miss a dose, take it as soon as you remember, as long as it is more than 1 hour before or 2 hours after a meal. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.
Are you currently using Cobenfy (xanomeline/trospium)?
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