Uses

What is Itovebi used for?

Itovebi (inavolisib) is commonly used to treat certain types of breast cancer. Itovebi is usually used in combination with other medicines.

Itovebi may also be used for other conditions as determined by your healthcare provider.

How does Itovebi work (mechanism of action)?

Itovebi is a specific kind of medicine called a kinase inhibitor. Kinases are enzymes that are responsible for sending and receiving signals in the body. These signals help your cells do important functions, such as grow properly. Itovebi blocks a kinase called phosphatidylinositol 3-kinase (PI3K). This kinase sends signals to cancer cells that help them grow and multiply. When Itovebi blocks the signals sent by PI3K, it helps to stop cancer cells from growing and multiplying and makes tumors shrink in size.

How is Itovebi supplied (dosage forms)?

Brands and other names

  • Itovebi

Dosage forms and strengths

  • 3 mg oral tablets
  • 9 mg oral tablets

How should I store Itovebi?

Itovebi should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Itovebi?

The most common side effects of Itovebi are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

There may be other side effects of Itovebi that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Itovebi?

While less common, the most serious side effects of Itovebi are described below, along with what to do if they happen.

Severe Allergic Reactions. Itovebi may cause allergic reactions, which can be serious. Stop taking Itovebi and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

High Blood Sugar. Itovebi can cause high blood sugar, which can sometimes be severe. Keep all appointments with your healthcare provider to check your blood sugar before and while taking Itovebi. You may need to check your blood sugar at home, especially during the first four weeks of taking Itovebi. If you have diabetes, you may need to have your blood sugar checked more often. You should drink plenty of water to stay hydrated while taking Itovebi. Call your healthcare provider if you have any of the following symptoms of high blood sugar.

  • Dry mouth and thirsty more than usual
  • Peeing more than usual (amount or how often you pee)
  • Increase in hunger
  • Tiredness
  • Feeling sick to your stomach, nausea, vomiting
  • Confusion
  • Your breath smelling fruity
  • Blurry vision
  • Losing weight
  • Feeling flushed
  • Dry skin

Mouth Sores. Itovebi can cause mouth sores, which can sometimes be severe. Call your healthcare provider if you have any of the following symptoms in your mouth that are severe.

  • Pain
  • Swelling
  • Ulcers or sores
  • Redness

Diarrhea. Itovebi can cause diarrhea, which can sometimes be severe. Severe diarrhea can sometimes lead to dehydration and kidney damage. It is important to drink plenty of water to keep you from getting dehydrated. Call your healthcare provider if you have any blood or mucus in your diarrhea or stomach pain with your diarrhea.

Warnings & Precautions

Who should not use Itovebi?

Allergies to Ingredients. People who are allergic to any of the following should not take Itovebi.

  • Inavolisib
  • Itovebi
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Itovebi.

What should I know about Itovebi before using it?

Your healthcare provider will likely do lab tests before you start taking Itovebi to make sure it is a good medicine for you to take.

Do not take Itovebi unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share Itovebi with other people, even if they have the same condition as you. It may harm them.

Keep Itovebi out of the reach of children.

Your dose should be taken at about the same time every day. Do not chew, cut, or crush Itovebi. The tablets should be swallowed whole.

If you can become pregnant or you can get your partner pregnant, you should use an effective method of birth control while you are taking Itovebi and for one week after stopping it. See the Pregnancy section for more details.

Itovebi may make it hard for you to become pregnant or to get your partner pregnant. Talk to your healthcare provider if you have any concerns. 

What should I tell my healthcare provider before using Itovebi?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Itovebi is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Diabetes or high blood sugar
  • Kidney problems
  • Menopause

Other Medicines and Supplements. Itovebi may interact with other medicines and supplements. Before taking Itovebi, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Itovebi may cause harm to an unborn baby. Your healthcare provider will likely test to make sure you are not pregnant before you start taking Itovebi. Tell your healthcare provider if you are, think you are, or plan to become pregnant. 

Breastfeeding. Do not take Itovebi while you are breastfeeding and for one week after your last dose. It is not known if Itovebi passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Itovebi?

For more information about Itovebi, you can visit the manufacturer’s website at www.itovebi.com or call them at 877-436-3683.

Interactions

Does Itovebi interact with foods or drinks?

There are no known interactions between Itovebi and foods or drinks.

It is unknown if drinking alcohol will affect Itovebi.

Does Itovebi interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Some other medicines may alter the blood levels of Itovebi, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Itovebi. Always check with your healthcare provider.

Does Itovebi (inavolisib) interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Itovebi?

If you or someone else has used too much Itovebi, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Itovebi?

If you miss a dose, take it as soon as you remember, as long as it is within nine hours of when you should have taken it. If it has been more than nine hours since you should have taken your dose, skip the missed dose and only take the next dose. Do not take double or extra doses. 

If you throw up after taking a dose, do not take another dose that day. Just take your normal dose the next day when you normally do.

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