RASPBERRY KETONE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Raspberry ketone is a chemical that is found in red raspberries and other fruits. It's popular for obesity, but it's not clear if it helps.

It's believed that raspberry ketone might increase metabolism, increase how quickly the body burns fat, and reduce appetite. But evidence in humans is limited. Raspberry ketone is also found in kiwifruit, peaches, grapes, apples, other berries, rhubarb, and the bark of yew, maple, and pine trees.

People use raspberry ketone for obesity, hair loss, male pattern baldness, and other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for RASPBERRY KETONE overview.

Side Effects

When taken by mouth: Raspberry ketone is commonly consumed in foods. When used as medicine, there isn't enough reliable information to know if raspberry ketone is safe. It is chemically related to a stimulant called synephrine, so it's possible that it might cause jitteriness, and increase blood pressure and heart rate.

Special Precautions and Warnings

Pregnancy and breast-feeding: Raspberry ketone is commonly consumed in foods. But there isn't enough reliable information to know if raspberry ketone is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Raspberry ketone might affect blood sugar levels. This might make it more difficult to control blood sugar in people taking medicines for diabetes.

Interactions ?

Moderate Interaction

Be cautious with this combination

Warfarin (Coumadin) interacts with RASPBERRY KETONE
Warfarin is used to thin the blood and prevent blood clots. Raspberry ketone might reduce the effects of warfarin, which could increase the risk for blood clots. If you take warfarin, talk with your healthcare provider before taking raspberry ketone.
Stimulant drugs interacts with RASPBERRY KETONE
Stimulants, such as amphetamines and cocaine, speed up the nervous system. By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Raspberry ketone might also speed up the nervous system. Taking raspberry ketone along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.

Dosing

There isn't enough reliable information to know what an appropriate dose of raspberry ketone might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View abstract.

Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.

Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View abstract.

Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View abstract.

Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.

Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.

Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.

Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.

Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.

Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.

Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.

Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.

Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.

Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.

Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.

Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.

Garcia, C. V., Quek, S. Y., Stevenson, R. J., and Winz, R. A. Characterization of the bound volatile extract from baby kiwi (Actinidia arguta). J Agric.Food Chem. 8-10-2011;59(15):8358-8365. View abstract.

Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.

Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.

Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.

Abdelraheem KM, Younis NN, Shaheen MA, Elswefy SE, Ali SI. Raspberry ketone improves non-alcoholic fatty liver disease induced in rats by modulating sphingosine kinase/sphingosine-1-phosphate and toll-like receptor 4 pathways. J Pharm Pharmacol. 2023;75(7):985-994. View abstract.

Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.

Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.

Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. View abstract.

Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.

Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 172: food additives permitted for direct addition to food for human consumption. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=59189f37d05de4dda57b07856d8d56f8&mc=true&node=pt21.3.172&rgn=div5#se21.3.172_1515

Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208. View abstract.

Kshatriya D, Li X, Giunta GM, et al. Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet. Nutr Res 2019;68:19-33. doi: 10.1016/j.nutres.2019.05.005. View abstract.

Li X, Wang Y, Yu C, et al. The signatures of liver metabolomics and gut microbiota in high-fat diet fed mice supplemented with rhododendrol. Food Funct 2022;13(24):13052-13063. View abstract.

Mir TM, Ma G, Ali Z, Khan IA, Ashfaq MK. Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study. J Diet Suppl 2019 Oct 11:1-16. doi: 10.1080/19390211.2019.1674996. [Epub ahead of print]. View abstract.

Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.

Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.

Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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RASPBERRY KETONE - Uses, Side Effects, and More