WHITE MULBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

White mulberry (Morus alba) is a shrub or tree native to China. It has a white colored fruit similar to a blackberry, but with an unpleasant taste.

Chemicals in white mulberry work similarly to some medicines used for type 2 diabetes. They slow the breakdown of sugar in the stomach so that it's absorbed more slowly into the blood. This helps the body keep blood sugar levels in a healthy range.

People commonly use white mulberry for diabetes. It is also used for high cholesterol levels, high blood pressure, the common cold, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for WHITE MULBERRY overview.

Side Effects

When taken by mouth: The powdered leaf of white mulberry is possibly safe for most people when taken for up to 12 weeks. It might cause bloating, constipation, gas, and loose stools in some people. There isn't enough reliable information to know if white mulberry berries are safe when taken as a medicine or what the side effects might be.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if white mulberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with WHITE MULBERRY
White mulberry leaf might lower blood sugar levels. Taking white mulberry leaf along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications moved by pumps in cells (Organic cation transporter 2 (OCT2) substrates) interacts with WHITE MULBERRY
Some medications are moved in and out of cells by pumps. White mulberry might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Dosing

White mulberry leaf powder or extract has most often been used by adults in doses of 0.8-1 gram three times daily for up to 3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. View abstract.

Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003;338:3-10. View abstract.

Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food 2007;10:41-8. View abstract.

Asano N, Oseki K, Tomioka E, et al. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 1994;259:243-55. View abstract.

Asano N, Yamashita T, Yasuda K, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 2001;49:4208-13. View abstract.

Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr 2007;16(Suppl 1):290-4. View abstract.

Da Villa G, Ianiro G, Mangiola F, et al. White mulberry supplementation as adjuvant treatment of obesity. J Biol Regul Homeost Agents 2014;28(1):141-5. View abstract.

Doi K, Kojima T, Makino M, et al. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull 2001;49:151-3. View abstract.

Du J, He ZD, Jiang RW, et al. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 2003;62:1235-8. View abstract.

El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 2006;78:2724-33. View abstract.

Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry (Morus alba L) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 2005;135:729-34. View abstract.

Gurukar MSA, Chilkunda ND. Morus alba leaf bioactives modulate peroxisome proliferator activated receptor ? in the kidney of diabetic rat and impart beneficial effect. J Agric Food Chem 2018;66(30):7923-34. doi: 10.1021/acs.jafc.8b01357. View abstract.

Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006;77:568-73. View abstract.

Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. View abstract.

Hwang KH, Kim YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors 2004;21:267-71. View abstract.

Jeong HI, Jang S, Kim KH. Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2022;2022:9282154. View abstract.

Jung S, Lee MS, Choi AJ, Kim CT, Kim Y. Anti-Inflammatory effects of high hydrostatic pressure extract of mulberry (Morus alba) fruit on LPS-stimulated RAW264.7 cells. Molecules 2019;24(7):0. pii: E1425. doi: 10.3390/molecules24071425. View abstract.

Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. View abstract.

Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol 2008;115:263-70. View abstract.

Lee SH, Choi SY, Kim H, et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 2002;25:1045-8. View abstract.

Li R, Xue Z, Jia Y, et al. Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice. Int J Biol Macromol 2021;192:452-460. View abstract.

Moore LM. Plant Guide: White Mulberry. United States Department of Agriculture, Natural Resources Conservation Service. Available at: https://plants.usda.gov/plantguide/pdf/pg_moal.pdf. (Accessed 3 September 2009).

Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. View abstract.

Oku T, Yamada M, Nakamura M, et al. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr 2006;95:933-8. View abstract.

Park KM, You JS, Lee HY, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol 2003;84:181-5. View abstract.

Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 2008;22:689-94. View abstract.

Taghizadeh M, Mohammad Zadeh A, Asemi Z, et al. Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial. Clin Nutr ESPEN 2022;49:68-73. View abstract.

Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. View abstract.

Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. View abstract.

Trimarco V, Izzo R, Stabile E, et al. Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endothelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High Blood Press Cardiovasc Prev 2015;22(2):149-54. doi: 10.1007/s40292-015-0087-2. View abstract.

Wan M, Li Q, Lei Q, Zhou D, Wang S. Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile. Foods 2022;11(12):1818. View abstract.

Wattanathorn J, Somboonporn W, Sungkamanee S, Thukummee W, Muchimapura S. A double-blind placebo-controlled randomized trial evaluating the effect of polyphenol-rich herbal congee on bone turnover markers of the perimenopausal and menopausal women. Oxid Med Cell Longev 2018; 21:2018:2091872. doi: 10.1155/2018/2091872. View abstract.

Yu Z, Fong WP, Cheng CH. The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther 2006;316:169-75. View abstract.

Diabetes: An Overview

Should You Change Your Type 2 Diabetes Medication?

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Conditions

Drugs & Supplements

Well-Being

More

WHITE MULBERRY - Uses, Side Effects, and More