TESTOLONE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Testolone is a type of chemical known as a selective androgen receptor modulator (SARM). It mimics the activity of testosterone in the body.

People use testolone to improve athletic performance and muscle strength, for breast cancer, and for other purposes, but there is no good scientific evidence to support these uses. Testolone might also be unsafe.

Testolone is not legally allowed in dietary supplements in the US, but it's still found in some products sold online. Testolone is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA).

Uses & Effectiveness ?

We currently have no information for TESTOLONE overview.

Side Effects

When taken by mouth: Testolone is possibly unsafe. There have been reports of heart attack and liver injury after use.

Special Precautions and Warnings

When taken by mouth: Testolone is possibly unsafe. There have been reports of heart attack and liver injury after use.

Pregnancy and breast-feeding: Testolone is possibly unsafe when taken by mouth while pregnant or breast-feeding. Avoid using.

Liver disease: Testolone might harm the liver. People with liver disease or a history of liver disease should avoid testolone.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications that can harm the liver (Hepatotoxic drugs) interacts with TESTOLONE
Testolone might harm the liver. Some medications can also harm the liver. Taking testolone along with a medication that can harm the liver might increase the risk of liver damage.

Dosing

Despite being banned in the US, testolone is still found in some dietary supplements sold online. It's also banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). There have been reports of heart attack and liver injury after use.

View References

REFERENCES:

2017-18 NCAA Banned Drugs List. National Collegiate Athletic Association (NCAA), June 5, 2017. https://www.ncaa.org/2017-18-ncaa-banned-drugs-list. Accessed: Sept 7, 2017

Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. View abstract.

Dynamic Technical Formulations, LLC. Issues a Voluntary Nationwide Recall of Tri-Ton Due to the Presence of Andarine and Ostarine. FDA Recalls, Market Withdrawals, & Safety Alerts, May 19, 2017. https://www.fda.gov/Safety/Recalls/ucm559700.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery. Accessed: Sept 7, 2017.

Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. View abstract.

LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. View abstract.

Miller CP, Shomali M, Lyttle CR, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2010;2(2):124-9. View abstract.

Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022;14(1):e21663. View abstract.

Selective Androgen Receptor Modulators (SARMs) - A Prohibited Class of Anabolic Agents. U.S. Anti-Doping Agency, November 18, 2015. https://www.usada.org/selective-androgen-receptor-modulators-sarms-prohibited-class-anabolic-agencts/. Accessed: August 30, 2017.

Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017

Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017

Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017

Yu Z, He S, Wang D, et al. Selective androgen receptor modulator RAD140 inhibits the growth of androgen/estrogen receptor-positive breast cancer models with a distinct mechanism of action. Clin Cancer Res 2017;23(24):7608-7620. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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